Effect of cold and cool herbs on liver mitochondria proteome of rats with heat symptom.
- Author:
Yi LI
;
De-Zhao LU
;
Li-Hua TANG
;
Xing-De WO
;
Zhen YANG
- Publication Type:Journal Article
- MeSH:
Animals;
Carbohydrate Metabolism;
drug effects;
Cold Temperature;
Drugs, Chinese Herbal;
pharmacology;
Energy Metabolism;
drug effects;
Hot Temperature;
Lipid Metabolism;
drug effects;
Male;
Mitochondria, Liver;
drug effects;
metabolism;
Proteome;
metabolism;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2013;38(23):4144-4147
- CountryChina
- Language:Chinese
-
Abstract:
In the 1960s, modern science began involving the essence of heat syndrome, but there have still no in-depth systematic studies on pathological mechanisms of heat syndrome and action mechanisms of cold and cool herbs. In this study, the animal model with heat syndrome was set up by feeding herbs with hot property, and then cold and cool herbs was applied in the experimental therapy. The two-dimensional electrophoresis and mass spectrometry technologies were adopted to compare the liver mitochondria proteome of the rats of the heat syndrome model and the ones treated with cold and cool herbs, so as to discover specificity-related proteins after heat syndrome and treatment with cold and cool herbs.
