Preparation of colon target pellets of Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion.
- Author:
Zhen-Hua CHEN
;
Yong-Mei GUAN
;
Wei-Feng ZHU
;
Ming YANG
;
Hong-Ning LIU
;
Shi-Lin YANG
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Absorption; Biomimetic Materials; metabolism; Colon; metabolism; Drug Compounding; methods; Drug Implants; Gastric Juice; metabolism; Humans; Pulsatilla; chemistry; Saponins; chemistry; metabolism; Surface Properties; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2013;38(24):4292-4297
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare colon target pellets of Pulsatilla total saponins.
METHODPulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion was prepared by the water solution-mixing method. Then plain pills of inclusion were prepared by the granulation-spheronization method, and coated by Glatt fluid bed.
RESULTThe dissolution of plain pills of Pulsatilla total saponins at 2 h was 16.0%, while that of plain pills of inclusion at 0.5 h was 91.9%. With Eudragit S100 as the coating material, TEC as the plasticizer and talcum power as the anti-adherent, when the coating weight was 12%, the coating efficiency was high, with almost no bonding and drug release of coated pellets in artificial gastric juice for 2 h. The accumulated drug release in artificial intestinal fluid for 4 h was less than 15%, and that in artificial colon fluid for 4 h was more than 90%.
CONCLUSIONCoated pellets of Pulsatilla total saponins-hydroxypropyl-beta-cyclodextrin inclusion showed a good colon targeted drug release in vitro, thus could be further developed to be oral colon targeted preparations.