Analysis on signaling pathway network of proliferation of neural stem cells.
- Author:
Qing-Shan LIU
;
Shu-Juan ZHUANG
;
Ke-Qin LI
;
Xu LI
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Proliferation;
Humans;
Neural Stem Cells;
cytology;
metabolism;
Signal Transduction;
Systems Biology
- From:
China Journal of Chinese Materia Medica
2014;39(3):407-411
- CountryChina
- Language:Chinese
-
Abstract:
Neural stem cells in brains have capacities of proliferation and differentiation, which is very critical to rebuild the cerebral cortex functions. Therefore, it is of great importance to find key targets and network pathways that regulate the proliferation of neural stem cells, which is also a pressing problem in the medical circle. With the Notch pathway as the core of the network, this paper summarized the advance of the bimolecular network system composed of Wnt, Shh, EGFR, cytokines and Notch signal, and analyzed such key nodes as Notch receptor, CBF1, NICD, Hesl, which may become potential targets of new-type drugs in the future. With the multi-component, multi-target, multi-lever characteristics, traditional Chinese medicines have many common grounds with the network pharmacology. The active component groups or active ingredients in traditional Chinese medicines are one of the material bases for showing their network pharmacological effect, which is worth exploring. This paper aims to provide a new strategy for the treatment of neurodegenerative disease and nerve injury with traditional Chinese medicines.
