Terpenoids and sterols from Ricinus communis and their activities against diabetes.
- Author:
Shen-Hua LI
;
Qing DENG
;
Li ZHU
;
Chun-Hua LAI
;
Heng-Shan WANG
;
Qin-Gang TAN
- Publication Type:Journal Article
- MeSH:
11-beta-Hydroxysteroid Dehydrogenase Type 1;
antagonists & inhibitors;
11-beta-Hydroxysteroid Dehydrogenase Type 2;
antagonists & inhibitors;
Animals;
Diabetes Mellitus;
drug therapy;
enzymology;
Humans;
Hypoglycemic Agents;
pharmacology;
therapeutic use;
Inhibitory Concentration 50;
Mice;
Ricinus;
chemistry;
Sterols;
pharmacology;
therapeutic use;
Terpenes;
pharmacology;
therapeutic use
- From:
China Journal of Chinese Materia Medica
2014;39(3):448-452
- CountryChina
- Language:Chinese
-
Abstract:
Seven terpenoids and three sterols were isolated from the methanol extracts of the aerial parts of Ricinus communis by chromatography methods and their structures were identified by spectra analysis as ficusic acid( 1), phytol(2), callyspinol(3) , lupeol(4), 30-norlupan-3beta-ol-20-one(5) , lup-20(29)-en-3beta,15alpha-diol(6) , acetylaleuritolic acid( 7), stigmast4-en-3-one(8) , stig-mast-4-en-6beta-ol-3-one(9) , and stigmast4-en-3,6-dione(10). Compounds 1-3 and 5-10 were obtained from this species for the first time and 5 and 6 showed significant inhibitive activity and good selectivity against 11beta-HSD of mouse and human in vitro. [Key words] Ricinus communis; terpenoids; sterols; 11beta-HSD
