Effects of qinghuang power combined Chinese herbs for shen reinforcing and Pi strengthening on activated T cells of myelodysplastic syndrome patients.
- Author:
Fei GAO
1
;
Rou MA
;
Xiao-hong YANG
;
Yong-gang XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Arsenicals; therapeutic use; Drugs, Chinese Herbal; therapeutic use; Female; Flow Cytometry; Humans; Lymphocyte Activation; Male; Middle Aged; Myelodysplastic Syndromes; drug therapy; immunology; metabolism; Phytotherapy; T-Lymphocytes, Regulatory; immunology; metabolism; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(4):443-447
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT OBJECTIVETo explore the effects of Qinghuang Power (QHP) combined Chinese herbs for Shen reinforcing and Pi strengthening (CHSRPS) on activated T cells of myelodysplastic syndrome (MDS) patients.
METHODSThe percentage and the absolute value of CD3+ CD28+, CD3+ CD28+ CD4+ CD8-, CD3+ CD28+ CD8+ CD4-, CD3+ CD25+, CD3+ CD25+ CD4+ CD8-, CD3+ CD25+ CD8+ CD4-, CD3+ DR+, CD3+ DR+ CD4+ CD8-, and CD3+ DR+ CD8+ CD4- in the peripheral blood of 24 MDS patients were detected by flow cytometry before and after treatment by QHP combined CHSRPS for 9 months. The changes of the differences in the aforesaid indices were analyzed between the effective group and the in-, and CD3 + effective group.
RESULTSThe absolute values of CD3+ CD28+, CD3+ CD28+ CD4+ CD8-, and CD3+ CD28+ CD8+ CD4- obviously decreased in the effective group(13 cases)after treatment (P <0.05). The percentages of the three indices also obviously decreased in the ineffective group (11 cases, P <0.05). After treatment, both the percentage and the absolute value of CD3+ CD25+ and CD3+ CD25+ CD4+ CD8- obviously decreased in the effective group (P <0.05). There was no statistical difference in the two indices of the ineffective group between before and after treatment (P >0.05).
CONCLUSIONSQHP combined CHSRPS could induce second signal loss by decreasing the expressions of in vitro costimulatory molecules, resulting in deactivation of T cells. It also could suppress the hyperfunction of the immune state in MDS patients, thus preventing normal hematopoietic cells from immune attack induced apoptosis.
