Preventive effects of jinghua weikang capsule on NSAID-induced injury to the mucosa of the small intestine: an experimental research.
- Author:
Rui-Feng DING
1
;
Yuan-Hu GUO
;
Wen-Peng HAN
;
Ai-Yu WANG
;
Li-Ping XIE
;
Peng-cheng ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; adverse effects; Diclofenac; adverse effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Esomeprazole; pharmacology; therapeutic use; Intestinal Mucosa; drug effects; pathology; Intestine, Small; drug effects; pathology; Male; Phytotherapy; Rats; Rats, Wistar
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(4):522-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preventive effects of jinghua weikang capsule (JWC) on nonsteroidal anti-inflammatory drugs (NSAIDs) induced injury to the mucosa of the small intestine.
METHODSThirty-two Wistar rats were randomly divided into four groups, i.e., the blank control group, the model group, the JWC group, and the esomeprazole group. Diclofenac was administered to rats in the model group, the JWC group, and the esomeprazole group at the daily dose of 15 mg/kg. JWC and esomeprazole was respectively given to those in the JWC group, and the esomeprazole group one day ahead. Normal saline was given to rats in the blank control group. Rats were killed 3 days later. The pathological changes of the small intestine were observed by hematoxylin and eosin stain.
RESULTSCompared with the blank control group, the general score for the small intestine (4.63 +/-0.52 vs 0.00 +/-0. 00) and the pathological score (4.00 +/-0.90 vs 0.00 +/-0. 00) obviously increased in the model group, showing statistical difference (P <0.05). Compared with the model group, the general score for the small intestine (1.88 +/-0.99) and the pathological score (2.11 +/-1.11) obviously decreased in the JWG group, showing statistical difference (P <0.05). Compared with the model group, the general score for the small intestine (2.75 +/-1.28) and the pathological score (2. 30 +/-0.94) obviously decreased in the esomeprazole group, showing statistical difference (P <0.05).
CONCLUSIONJWC could prevent NSAIDs induced injury to the mucosa of the small intestine.