Study on inhibitory effects of Taxus chinensis var. mairei aqueous extract on the proliferation of tumor cells.
- Author:
Jing ZHANG
1
;
Qi-Jin SHU
;
Ji-Liang GAO
;
Le ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; Cell Line, Tumor; Cell Proliferation; drug effects; Humans; MCF-7 Cells; Plant Extracts; pharmacology; Taxus; chemistry
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(6):805-809
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the inhibitory effects of Taxus chinensis var. mairei Aqueous Extract (TAE) on SGC-7901 and MCF-7 cells, and to explore its mechanisms.
METHODSThe inhibitory effects of TAT and Paclitaxel on the proliferation of SGC-7901 and MCF-7 cells were tested by MTT method. Their effects on the morphology of SGC-7901 and MCF-7 cells were observed by microscope. Its effects on the cell apoptosis were detected by flow cytometry.
RESULTSThe TAE had inhibitory effects on the proliferation of tumor cells, and its mechanisms were correlated to inducing the apoptosis of tumor cells.
CONCLUSIONTAE had inhibitory effects on the proliferation of tumor cells.
