Evaluation of the key indicators in the pituitary-target gland axes in the animal model with shenyang deficiency syndrome using factor analysis.
- Author:
Xiu-Feng WANG
1
;
Jing LI
;
Lei ZHANG
;
Na MA
;
Lai-Cheng LUO
;
Qing-Hua WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Estradiol; analysis; Factor Analysis, Statistical; Follicle Stimulating Hormone; analysis; Hydrocortisone; analysis; Luteinizing Hormone; analysis; Male; Pituitary-Adrenal System; physiopathology; Rats; Rats, Sprague-Dawley; Testosterone; analysis; Thyrotropin; analysis; Thyroxine; analysis; Yang Deficiency; physiopathology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(6):825-829
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the key indicators in the pituitary-target gland axes in the animal model of Shen-yang deficiency syndrome (SYDS).
METHODSThe 8 biological indicators [thyroid stimulating hormone (TSH), 3, 3', 5-triiodothyronine (T3), thyroxine (T4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), adrenocorticotropic hormone (ACTH), and cortisol (CORT)] in the pituitary-target gland axes were grouped using factor analysis. Then the sensitivity of every indicator was calculated according to the sensitivity function defined in this paper, so as to find all the most sensitive indicators in every group as key indicators of SYDS.
RESULTSThe key indicators in the early period of SYDS were T, LH, T4, and CORT. The key indicators in the middle period were LH,T, CORT, and ACTH. The key indicators in the late period were LH, T, CORT, and FSH.
CONCLUSIONST, LH, and CORT were the common key indicators of the three periods, and other different key indicator of SYDS in the early, middle and late period were T4, ACTH, and FSH respectively, which changed from the thyroid axis to the adrenal axis and then to the gonadal axis as the period changed. The key indicators in the late period were mainly in the gonadal axis, showing gonadal dysfunction in the late period.
