Association of the CYP1B1 gene polymorphism with susceptibility to endometriosis.
- VernacularTitle:CYP1B1基因多态性与子宫内膜异位症易感性的相关研究
- Author:
Yi-ge LI
1
;
Xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aryl Hydrocarbon Hydroxylases; genetics; Case-Control Studies; Cytochrome P-450 CYP1B1; Endometriosis; genetics; Exons; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy
- From: Chinese Journal of Medical Genetics 2009;26(1):66-69
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between gene polymorphisms of cytochrome P450 1B1 (CYP1B1) in exon 2 codon 119 (G-T) and exon 3 codon 432 (C-G) and the susceptibility to endometriosis.
METHODSAllele-specific polymerase chain reaction was used to analyze the gene polymorphisms in 55 cases of endometriosis and 45 cases of normal controls.
RESULTSThe frequencies of alleles G and T in codon 119 G/T of CYP1B1 gene showed a significant difference between the endometriosis group and the control group (P<0.05), with an odds ratio of 2.061. There was a significant difference in the frequencies of genotypes G/G, G/T and T/T between the two groups (P<0.05). Compared with wild-type G/G, the susceptibility of endometriosis with genotypes T/T and G/T was 2.625 and 3.214 fold, respectively. In the population with combined genotypes of CYP1B1 codon 119 GT or GG-codon 432 CC, statistically significant difference was observed between cases and controls (GT+CC vs GG+CC, OR=2.976, P<0.05).
CONCLUSIONThe gene polymorphisms of CYP1B1 in exon 2 codon 119 may be a genetic risky factor for endometriosis. The combination of CYP1B1 -GT and CYP1B1 -CC may act as a risky factor in the development of endometriosis.
