Advances in the studies of the dysbindin gene in schizophrenia.
10.3760/cma.j.issn.1003-9406.2009.02.012
- VernacularTitle:Dysbindin基因在精神分裂症中的研究进展
- Author:
Gao-feng ZHAO
1
;
Hong DENG
;
Yan-chun YANG
;
Ying CHEN
Author Information
1. West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
- Publication Type:Journal Article
- MeSH:
Brain;
metabolism;
Carrier Proteins;
genetics;
physiology;
Cognition Disorders;
genetics;
physiopathology;
Dysbindin;
Dystrophin-Associated Proteins;
Genetic Predisposition to Disease;
Genotype;
Humans;
Polymorphism, Single Nucleotide;
Schizophrenia;
genetics;
metabolism;
pathology
- From:
Chinese Journal of Medical Genetics
2009;26(2):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Recent reports indicate that the dysbindin gene located on chromosome 6p22.3 is a major susceptibility gene for schizophrenia. In the brain, the dysbindin gene may influence glutamatergic neurotransmission by multiple post- and pr- synaptic mechanisms. This paper reviews the research progress on the dysbindin gene in schizophrenia, including the dysbindin gene and its product, the possible pathogenic mechanisms, the association study of the dysbindin gene with schizophrenia, and the cognitive decline caused by the dysbind in variations.
