Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing.
- Author:
Su-qing GAO
1
;
Hong-yan ZOU
;
Liang-hong CHENG
;
Shi-zheng JING
;
Zhi-hui DENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Base Sequence; China; ethnology; Female; Genetics, Population; HLA Antigens; analysis; genetics; immunology; HLA-B Antigens; analysis; genetics; HLA-DQ Antigens; analysis; genetics; HLA-DQ beta-Chains; HLA-DR Antigens; analysis; genetics; HLA-DRB1 Chains; Haplotypes; Humans; Male; Population Groups
- From: Chinese Journal of Medical Genetics 2009;26(2):228-232
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the polymorphism and haplotypes of HLA-A, B, Cw, DRB1 and DQB1 loci in Chinese Han population.
METHODSA total of 186 unrelated healthy individuals from southern China were analyzed by sequence-based typing. Two-, three-, and five-locus haplotypes were estimated using the Expectation Maximization Algorithm. RESULTST: Twenty-eight alleles for the HLA-A locus, 49 HLA-B alleles, 24 HLA-C alleles, 29 HLA-DRB1 alleles and 20 HLA-DQB1 alleles were detected. The A*0207-B*4601(10.81%), A*3303-B*5801(6.14%), B*4601-DRB1*0901(6.22%), B*4001*-DRB1*0901(3.78%), DRB1*090-DQB1*0303 (12.16%) and DRB1*1202-DQB1*0301(8.38%), A*0207-B*4601-Cw*0102 (10.75%), A*3303-B*5801-Cw*0302 (5.14%), A*0207-B*4601-DR*0901(5.07%), A*3303-B*5801-DRB1*0301(2.96%), A*0207-B*4601-Cw*0102-DRB1*0901-DQB1*0303(4.87%) and A*1101-B*1301-Cw*0304-DRB1*1501-DQB1*0601(2.43%) were the most common haplotypes in the southern Chinese Han population.
CONCLUSIONThe results have shown the characteristics of the five HLA loci haplotype distribution and provided more information in anthropology, disease association studies and transplantation.
