Association between HRE-2 gene polymorphism at codon 655 and genetic susceptibility of colorectal cancer.
- Author:
Xia LIANG
1
;
Yong-jing ZHANG
;
Bing LIU
;
Qin NI
;
Ming-juan JIN
;
Xin-yuan MA
;
Kai-yan YAO
;
Qi-long LI
;
Kun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; Codon; genetics; Colorectal Neoplasms; genetics; Female; Genetic Predisposition to Disease; genetics; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptor, ErbB-2; genetics
- From: Chinese Journal of Medical Genetics 2009;26(3):302-305
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the distribution of HER-2 genetic polymorphism at codon 655 and its association with susceptibility of colorectal cancer in Chinese.
METHODSA population-based case-control study was carried out. 292 patients with colorectal cancer and 842 healthy controls were interviewed. Meanwhile, the genetic polymorphism of HRE-2 was detected using polymerase chain reaction-restriction fragment length polymorphism.
RESULTSThe frequencies of Ile/Val+Val/Val genotypes and Val allele were both higher in cases (25.34% and 13.36%) than those in controls (18.41% and 9.74%) (P<0.05). Compared with Ile/Ile genotype, Ile/Val+Val/Val genotypes were significantly associated with colorectal cancer [ORadjusted=1.54, 95% CI: 1.11-2.14]. The adjusted odds ratio of interactions between this polymorphism and smoking, alcohol drinking were 1.43 (95%CI: 0.88-2.30) and 1.29 (95%CI: 0.73-2.29), respectively.
CONCLUSIONThe present findings suggest that HER-2 genetic polymorphism at codon 655 may be associated with the risk of colorectal cancer in Chinese. In addition, there are no interactions between this polymorphism and smoking, alcohol drinking, respectively.
