Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus.
- VernacularTitle:线粒体基因组np16181～16193区基因变异与2型糖尿病的关联研究
- Author:
Fang-jian CHEN
1
;
Hong YU
;
Hong LIN
;
Chao-hui HU
;
Ya-guo HU
;
Jian-xin LV
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Complementarity Determining Regions; genetics; DNA Mutational Analysis; DNA, Mitochondrial; analysis; Diabetes Mellitus, Type 2; genetics; Female; Genetic Predisposition to Disease; Genome, Mitochondrial; genetics; Humans; Male; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2009;26(3):340-344
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the mitochondrial DNA region np16181-16193 variations with type 2 diabetes mellitus (T2DM).
METHODSBlood samples of 199 unrelated T2DM patients and 205 normal controls were collected to detect the mitochondrial DNA region np16181-16193 variations by PCR and sequencing, and to analyze the association of the variations with the major clinical symptoms.
RESULTSThe mitochondrial DNA np16181-16193 region is a hypervariable area, with several polymorphisms. Four types of np16181-16193 region variations were found only in T2DM. The 1-hour postprandial blood glucose (P1BG) in the T2DM individuals with np16181-16193 region variations was significantly higher than those without variations (P<0.05), while there was no significant difference in other biochemical parameters (P>0.05).
CONCLUSIONThe mitochondrial DNA np16181-16193 variations could not be regarded as a risk factor for T2DM.
