Application of fluorescence in situ hybridization in prenatal diagnosis of complex chromosomal abnormalities.
- Author:
Yan-yan SHEN
1
;
Jian LI
;
Hui KONG
;
Hui-nan WU
;
Qiong WU
;
Yun-sheng GE
;
Xin-li HUANG
;
Yu-lin ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Amniotic Fluid; chemistry; Chromosome Aberrations; Female; Fetal Blood; chemistry; Humans; In Situ Hybridization, Fluorescence; methods; Pregnancy; genetics; Prenatal Diagnosis; methods
- From: Chinese Journal of Medical Genetics 2009;26(5):529-532
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the application of fluorescence in situ hybridization (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities.
METHODSEleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord blood) with complex chromosomal abnormalities detected by routine G-banding, were further analyzed by FISH.
RESULTSThe FISH technique confirmed the results of balanced chromosome rearrangements detected by G-banding, and clarified the structure of the derivative chromosomes in the 3 amniocentesis samples and the origin of the mark chromosomes in the 2 cord blood samples.
CONCLUSIONFISH can be used to diagnose the complex chromosomal abnormalities accurately in prenatal diagnosis, and can provide very useful genetic information for clinical diagnosis and treatment.
