Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles.
- Author:
Jun HE
1
;
Shi-xiang HOU
;
Jian-fang FENG
;
Ben-qin CAI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Area Under Curve; Biological Availability; Drug Carriers; Drug Delivery Systems; Excipients; Fatty Acids; Female; Male; Milk Thistle; chemistry; Nanostructures; Particle Size; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Silymarin; administration & dosage; isolation & purification; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2005;30(21):1651-1653
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparuicles.
METHODSolid lipid nanoparticles (SLN) of various sizes (150 nm, 500 nm and 1000 nm) using Compritol 888 ATO as the material and silymarin (SM) as a model drug were prepared. Silybinin concentration in plasma of rats were determined by RP-HPLC with UV detector. The main pharmacokinetic parameters were calculated by 3p97.
RESULTResults showed that the AUC of 150 nm SLN was 2.08 fold that of 500 nm SLN and 2.54 fold of 1000 nm SLN treated orally to rats (P < 0.05). The oral bioavailability of 150 nm SLN was remarkably higher than the other two size SLN.
CONCLUSIONThis has important implications in designing of SM-SLN as a new oral drug delivery system.
