Pharmacokinetic study of intraperitoneal chemotherapy with HCPT.
- Author:
Meng YE
1
;
Xiao-xia LIN
;
Hong-ming PAN
;
Nan LI
;
Fang LOU
;
Wei JIN
;
Yu ZHENG
;
Jing-min WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; administration & dosage; pharmacokinetics; Area Under Curve; Ascitic Fluid; metabolism; Camptothecin; administration & dosage; analogs & derivatives; pharmacokinetics; Dogs; Infusions, Parenteral; Male
- From: China Journal of Chinese Materia Medica 2005;30(20):1610-1612
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration.
METHODSix dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol. The concentration of HCPT in all samples was determined by high performance liquid chromatography (HPLC).
RESULTThe area under the curve (AUC) of peritoneal fluids was significantly highly as compared to the AUC of femoral vein and portal vein (P < 0.001).
CONCLUSIONThese experiments demonstrate that intraperitoneal chemotherapy has significant effect on the pharmacokinetics of IP route of HCPT administration. This method should be a more reasonable chemotherapy for the prevention of recurrence and liver metastasis of gastric cancer, colon cancer and ovary cancer after radical resection.
