Effects of Astragalus membranaceus and Panax notoginseng on the transformation of bone marrow stem cells and proliferation of EPC in vitro.
- Author:
Bo-hua YANG
1
;
Ling-qun ZHU
;
Juan-zi ZHANG
;
Fu-ling NIU
;
Wei CUI
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD34; metabolism; Astragalus membranaceus; chemistry; Cell Proliferation; drug effects; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Endothelial Cells; cytology; drug effects; metabolism; Ginsenosides; administration & dosage; isolation & purification; pharmacology; Hematopoietic Stem Cells; cytology; drug effects; metabolism; Humans; Panax notoginseng; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2005;30(22):1761-1763
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect and the possible mechanism underlying the promotional effect of Astragalus membranaceus and Panax notoginseng on the transformation of bone narrow stem cells and proliferation of EPC.
METHODThe marrow blood was collected in the patients with ischemia of lower limbs and BM-MNCs were separated and proliferated under different conditions. A. morphologic observation was performed and the ratio of CD34+ cells was measured.
RESULTThe shuttle shaped cells lined up as bunches with several round cells scattered. The ratio of CD34+ cells was significantly increased in groups treated with medium (P < 0.01) and lower (P < 0.05) dosages of A. membranaceus and medium (P < 0.01) and high dosages (P < 0.01) of P. notoginseng respectively as compared with control group.
CONCLUSIONA. membranaceus and P. notoginseng can promote the transformation and proliferation of EPC.
