Study on the preparation and bio-distribution of silybin lipid nanospheres.
- Author:
Xi-Ming XU
1
;
Qiang LI
;
Yuan ZHU
;
Song SHEN
;
Zhu SHEN
;
Jiang-Nan YU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Liver; metabolism; Mice; Nanoparticles; Particle Size; Phospholipids; Random Allocation; Silymarin; administration & dosage; pharmacokinetics; Tissue Distribution
- From: China Journal of Chinese Materia Medica 2005;30(24):1912-1914
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare silybin lipid nanospheres (SLN) and to evaluate the properties of morphology, particle size and the silybin distribution in mice.
METHODSilybin lipid nanospheres were prepared by thin film emulsion-high pressure homogenization technique. Concentrations of silybin in mice blood, liver, spleen, lung, kidney, brain, heart, stomach after oral administration were determined by high performance liquid chromatography.
RESULTScanning electron micrograph showed that most of the SLN were spherical. The average diameter from photon correlation spectrometer was 148.9 nm with the polydispersity 0.17. Body distribution data indicated that SLN could increase the distribution of silybin in blood and liver, decrease the amount of silybin in stomach as compared with the preparation on market, and the drug targeting index (DTI) in liver was 1.81.
CONCLUSIONSLN can increase the uptake of silybin in liver after oral administration, which must benefit the hepatitis treatment.
