Comparative Study of Intralesional Triamcinolone Alone or in Combination with 5-Fluorouracil for the Treatment of Keloid and Hypertrophic Scars.
- Author:
Chang Sun YOO
1
;
Chul Woo KIM
;
Sang Seok KIM
Author Information
1. Department of Dermatology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. kim937121@naver.com
- Publication Type:Comparative Study ; Original Article
- Keywords:
5-Fluorouracil;
Hypertrophic scar;
Keloid;
Triamcinolone acetonide
- MeSH:
Cicatrix, Hypertrophic;
Collagen;
Cosmetics;
Erythema;
Fluorouracil;
Humans;
Hyperpigmentation;
Injections, Intralesional;
Keloid;
Pliability;
Pruritus;
Triamcinolone;
Triamcinolone Acetonide;
Wound Healing
- From:Korean Journal of Dermatology
2012;50(2):123-129
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Keloids and hypertrophic scars may complicate wound healing secondary to trauma or surgery. They are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems for patients. OBJECTIVE: The purpose of this study was to evaluate the efficacy of using a 5-FU (Fluorouracil)/Triamcinolone acetonide (TCN) mixture to treat keloids and hypertrophic scars. Further, the results were compared via TCN alone. METHODS: Patient chart from 2007 to 2011 were reviewed. Patients were stratified into 2 groups: (1) intralesional injection of TCN 0.1 ml (40 mg/ml) mixed with 5-FU 0.9 ml (50 mg/ml), every 2 weeks; (2) intralesional injection of TCN (20 mg/ml), every 2 weeks. Lesions were assessed for height, erythema, pliability, pruritus, pain/tenderness, patient-self assessment and side effects at baseline (initiation of treatment) and at weeks 2, 4, 6. RESULTS: There has been 23 patients (43 lesions) that completed the study. At the 2, 4, 6 week visits, both groups showed an acceptable improvement in all nearly parameter., However, in comparison between the groups, there was no statistically significant differences (p>0.05). Complications such as injection pain and hyperpigmentation were seen in both treatment groups. CONCLUSION: The overall efficacy of 5-FU/TCN mixture was comparable with TCN alone.
