Chemical constituents from tuber of Cremastra appendiculata.
- Author:
Wen-bin XIA
1
;
Zhen XUE
;
Shuai LI
;
Su-juan WANG
;
Yong-chun YANG
;
Ding-xiang HE
;
Guang-lun RAN
;
Ling-zhong KONG
;
Jian-gong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Adenosine; chemistry; isolation & purification; pharmacology; Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; pharmacology; Benzaldehydes; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; drug effects; Humans; Inhibitory Concentration 50; Orchidaceae; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Sucrose; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2005;30(23):1827-1830
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents from the tuber of the planted Cremastra appendiculata.
METHODThe compounds were isolated by column chromatography over silica gel, Sephadex LH-20 and RP-HPLC, and their structures were elucidated on the basis of spectroscopic analysis.
RESULTEight compounds were isolated, and identified as cirrhopetalanthrin (I), 7-hydroxy-4-methoxyphenanthrene-2-O-beta-D-glucoside (II), 4-(2-hydroxyethyl)-2-methoxyphenyl-1-O-beta-D-glucopyranoside (III), tyrosol 8-O-beta-D-gluco-pyranoside (IV), vanilloloside (V), p-hydroxybenzaldehyde (VI), sucrose (VII), adenosine (VIII).
CONCLUSIONThese compounds are isolated from this plant for the first time. All compounds were evaluated against human colon cancer (HCT-8), human hepatoma (Bel7402), human stomach cancer(BGC-823), human lung adenocarcinoma (A549), human breast cancer (MCF-7), and human ovarian cancer (A2780) cell lines, and cirrhopetalanthrin (I) showed non-selective moderate cytotoxicity with IC50 values of 8.4-13.3 micromol x L(-1), and other compounds were inactive.
