Effect of gufuhuo decoction on local apoptosis of steroid-induced necrosis of femoral head.
- Author:
Wei-ming TIAN
1
;
Wen-zhi WANG
;
Xin-guo WANG
;
Guo-hua XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Femur Head Necrosis; chemically induced; pathology; In Situ Nick-End Labeling; Leeches; chemistry; Male; Materia Medica; isolation & purification; pharmacology; Osteoblasts; pathology; Osteocytes; pathology; Plants, Medicinal; chemistry; Prednisone; Rabbits; Random Allocation
- From: China Journal of Chinese Materia Medica 2005;30(23):1848-1851
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the bone specimen of SANFH (steroid-induced avascular necrosis of femoral head) and the effect of Gufuhuo decoction on local apoptosis of SANFH.
METHODModel rabbits of necrosis of femoral head, made by intragluteal injection with prednisone acetate, were killed after 6 weeks to study the apoptosis by means of TUNEL.
RESULTA great number of faded osteocytes and osteoblasts existed in specimen of SANFH. There was significant difference in apoptosis indexes between model and control group, Gufuhuo decoction and Xianlinggubao group (P < 0.05).
CONCLUSIONIn the course of SANFH, the necrosis results from the interaction of apoptosis and necrosis of steroid-induced osteocytes and osteoblasts. Gufuhuo decoction has some effects on improving apoptosis and necrosis of SANFH.
