New targets of anticancer drugs and their pathways.
- Author:
Lan-Lan YIN
1
;
You-Qun WANG
Author Information
1. Research Division of Pharmacology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
- Publication Type:Journal Article
- MeSH:
Antigens, Neoplasm;
drug effects;
metabolism;
Antineoplastic Agents;
pharmacology;
Drug Delivery Systems;
Drug Design;
Humans;
Male;
NF-kappa B;
drug effects;
metabolism;
Phosphatidylinositol 3-Kinases;
drug effects;
metabolism;
Proto-Oncogene Proteins c-bcl-2;
drug effects;
metabolism;
Retinoblastoma Protein;
drug effects;
metabolism;
Testis;
drug effects;
metabolism
- From:
National Journal of Andrology
2002;8(3):221-223
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews recent advances in apoptosis on the pathway inducing cancer cell to death, including Bcl-2 family pathway, NF-kappa B pathway, P13K/Akt pathway, Rb gene and p53 gene, especially the targets of anticancer drug in these pathways. It could be useful for the anticancer drug design and estimate. Furthermore, those cancer/testis antigen gene products are potential targets for antigen-specific immunotherapy of carcinoma.
