The changes of IL-1 and NO levels in the testes of rats with experimental varicocele.
- Author:
Li-Ping CHEN
1
;
Shu-Qiu WANG
;
Yu-Zhen ZHAO
;
Lei LIU
;
Shu-Xiang WANG
;
Ya-Zhen LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Interleukin-1; metabolism; Male; Nitric Oxide; metabolism; Rats; Rats, Wistar; Testis; metabolism; ultrastructure; Varicocele; metabolism
- From: National Journal of Andrology 2002;8(2):125-126
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC.
METHODSMale adult Wistar rats were divided into two groups randomly, VC group (n = 30) and pseudo-operation group (n = 20), and the levels of IL-1 and NO in the testes were determined and compared.
RESULTSThe levels of IL-1 and No of left tests in VC group were higher than those in pseudo-operation group, respectively(P < 0.01). While the levels of IL-1 and NO of right testes between two groups were not significantly different (P > 0.05). More over, the level of IL-1 correlated significantly with that of NO(r = 0.572, P < 0.01).
CONCLUSIONSThe results revealed that the changes of IL-1 and NO levels in the testes of rats with VC might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility.
