Preliminary investigation of relationship between sperm apoptosis and male infertility.
- Author:
Guang-Rong WANG
1
;
Zeng-Di ZHOU
;
Zheng-Min GE
;
Ming-Jun ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; Flow Cytometry; Humans; Infertility, Male; pathology; Male; Spermatozoa; pathology
- From: National Journal of Andrology 2002;8(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo evaluate the relationship between sperm apoptosis and male infertility.
METHODSPercentage of apoptotic sperm (PAS) in spermatozoa of fertile and infertile men were tested by flow cytometry (FCM).
RESULTSSperm apoptosis had happened in all different people. PAS in fertile and infertile group was (4.28 +/- 1.66)% and (18.67 +/- 8.55)% respectively, and difference was significant between two groups (P < 0.01). There was negative correlation between PAS and semen volume, sperm density, percentage of forward motility, percentage of normal morphology (P < 0.01).
CONCLUSIONSThere was very close relationship between sperm apoptosis and male infertility. FCM used to test sperm apoptosis is rapid, accurate, objective and reliable to analyse sperm functions and male fertility.
