Effect of gamma-aminobutyric acid on the sperm acrosin activity.

Author: Shu-Ling BIAN ¹ ; Wei ZHANG ; Hui ZHU ; Jiang NI ; Lan-Chun YAO ; Liang CHEN
Author Information

1. Department of Physiology, Harbin Medical University, Harbin, Heilongjiang 150086, China.
Publication Type:Journal Article
MeSH: Acrosin; metabolism; Humans; Male; Spermatozoa; drug effects; immunology; metabolism; gamma-Aminobutyric Acid; pharmacology
From: National Journal of Andrology 2002;8(5):326-328
CountryChina
Language:Chinese
Abstract:
OBJECTIVESTo investigate the effect of gamma-aminobutyric acid (GABA) on the sperm acrosin activity in normal men and positive antisperm antibody (AsAb) men.
METHODSSperm acrosin activity was detected by BAEE/ADH method.
RESULTSGABA could increase the sperm acrosin activity in normal and AsAb positive patients (P < 0.01). The results also indicated that GABA significantly increased Na(+)-K(+)-ATPase activity (P < 0.01), Ca(2+)-ATPase activity (P < 0.05) and SOD activity (P < 0.01) of sperm.
CONCLUSIONSThe results demonstrated that GABA could influence the sperm acrosin activity.