Effect of Huanshuai Recipe Oral Liquid (characters: see text) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis.
- Author:
Xiu-juan WANG
1
;
Xiang-rong RAO
2
;
Shen LI
1
;
Li WANG
1
;
Chang LIU
1
;
Gai-hua ZHANG
1
;
Dong-yan HAN
1
;
Yu ZHAO
1
;
Nan-nan ZHANG
3
;
Xue-xia LI
4
;
Shuai CHEN
5
Author Information
- Publication Type:Journal Article
- Keywords: Chinese medicine; Huanshuai Recipe Oral Liquid; atherosclerotic renal artery stenosis; renal dysfunction
- MeSH: Administration, Oral; Aged; Atherosclerosis; drug therapy; Disease Progression; Drugs, Chinese Herbal; pharmacology; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Lipids; blood; Male; Renal Artery Obstruction; drug therapy; Treatment Outcome
- From: Chinese journal of integrative medicine 2015;21(11):811-816
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of Huanshuai Recipe Oral Liquid ([characters: see text], HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS).
METHODSA total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood urea nitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular filtration rate (eGFR) and CM syndrome score were compared between groups.
RESULTSAfter treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased (P<0.05 or P<0.01), and the eGFR in the treatment group were significantly increased (P<0.05).
CONCLUSIONHSR can effectively improve the renal function and clinical symptoms of ARAS patients.
