Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.

Fan Pan; Tian-yuan YU; Steven Wong; Si-tong Xian; Meng-qian LU; Jian-cong WU; Yu-feng Gao; Xiao-qin LI; Nan Geng; Bin-bin Yao

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Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats.

Author: Fan PAN ¹ ; Tian-Yuan YU ² ; Steven WONG ¹ ; Si-Tong XIAN ¹ ; Meng-Qian LU ¹ ; Jian-Cong WU ³ ; Yu-Feng GAO ⁴ ; Xiao-Qin LI ⁵ ; Nan GENG ⁶ ; Bin-Bin YAO ¹
Author Information

1. Collage of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China.
2. Collage of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China. yutianyuan@sina.com.
3. The 2nd Massage Department, Beijing Massage Hospital, Beijing, 100035, China.
4. Department of Encephalopathy of Mogol Medicine, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia Autonomous Region, 028000, China.
5. Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330019, China.
6. Department of Massage Physiotherapy, Beijing University of Chinese Medicine Dongfang Hospital, Beijing, 100078, China.
Publication Type:Journal Article
Keywords: Chinese medicine; massage; peripheral neuropathy; physical therapy
From: Chinese journal of integrative medicine 2017;23(8):617-624
CountryChina
Language:English
Abstract:
OBJECTIVETo elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury, and to detect the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1), which is thought to play an important role in nerve regeneration.
METHODSThirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats (sham-operated group) went through a sham operation. Control group was given no treatment while tuina group received tuina therapy since day 7 post-surgery. Tuina treatment was performed once a day and lasted for 20 days. The sciatic functional index was examined every 5 days during the treatment session. The rats' gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tPA and PAI-1.
RESULTSTuina therapy improved the motor function of sciatic nerve injured rats (P<0.05), however, it did not increase muscle volume (P<0.05). Tuina downregulated the levels of tPA and PAI-1 (P<0.05).
CONCLUSIONSThe present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury.