Effect of Danlou Tablet () on peri-procedural myocardial injury among patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndrome: A study protocol of a multicenter, randomized, controlled trial.
- Author:
Lei WANG
1
;
Shuai MAO
1
;
Jian-yong QI
2
;
Yi REN
2
;
Xin-feng GUO
1
;
Ke-ji CHEN
3
;
Min-zhou ZHANG
4
Author Information
- Publication Type:Journal Article
- Keywords: Chinese medicine; Danlou Tablet; non-ST-segment elevation acute coronary syndrome; percutaneous coronary intervention; peri-procedural myocardial infarction
- MeSH: Acute Coronary Syndrome; diagnostic imaging; drug therapy; Drugs, Chinese Herbal; therapeutic use; Electrocardiography; Endpoint Determination; Humans; Myocardium; pathology; Percutaneous Coronary Intervention; Sample Size; Ultrasonography
- From: Chinese journal of integrative medicine 2015;21(9):662-666
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDIt has been shown that administration of statins reduced the risk of peri-procedural myocardial damage. However, it remains unclear whether Chinese medicine Danlou Tablet (), similar to statins, may protect patients undergoing percutaneous coronary intervention (PCI) from peri-procedural myocardial damage.
OBJECTIVETo demonstrate the hypothesis whether treatment with Danlou Tablet would improve clinical outcome in patients undergoing selective PCI with non-ST elevation acute coronary syndrome (NSTE-ACS) in China.
METHODSApproximately 220 patients with unstable angina or non-ST-segment elevation myocardial infarction undergoing PCI will be enrolled and randomized to Danlou Tablet treatment (4.5 g/day for 2 days before intervention, with a further 4.5 g/day for 90 days thereafter) or placebo. All patients will not receive Danlou Tablet before procedure. The primary end point is to evaluate the incidence of cardiac death, myocardial infarction or unplanned re-hospitalization and revascularization after 30 days in patients undergoing selective PCI treated with Danlou Tablet compared with placebo. Secondary endpoints include the incidence of peri-procedural myocardial injury, 3-month clinical outcomes, the quality of life and Chinese medicine syndromes assessment.
CONCLUSIONThis study protocol will provide important evidence of Danlou Tablet treatment on the peri-procedural myocardial injury in patients with NSTE-ACS undergoing selective PCI, which may support a strategy of routine Danlou Tablet therapy to improve the clinical outcomes.