Effects of Tiaoxin and Zishen prescription on hippocampus neurotransmitters in Alzheimer's disease rats.
- Author:
Xiu-qi BAO
1
;
Ben LIU
;
Bing SUN
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; drug therapy; metabolism; Animals; Drugs, Chinese Herbal; therapeutic use; Hippocampus; metabolism; Male; Neurotransmitter Agents; metabolism; Phytotherapy; Rats; Rats, Wistar; Serotonin; metabolism
- From: Chinese Journal of Applied Physiology 2005;21(1):55-57
- CountryChina
- Language:Chinese
-
Abstract:
AIMA method of stereotaxic apparatus was employed to damage the nucleus basalis of Meynert, and the effects of Tiao-xinzishen prescriptions on neurotransmitters such as ACh, 5-HT and NE in hippocampus were observed.
METHODSRats were placed on the brain stereotaxic apparatus and received a bilateral lesion of Meynert by IA injection, according to the atlas of Daxinos and Watson. After seven days of lesion, AD rats were selected. Rats were treated with Tiaoxin or/and Zishen prescription for 20 days, respectively. Hippocampus ACh was measured by spectrophotometer and 5-HT and NE by high performance liquid chromatography (HPLC).
RESULTSThe contents of hippocampus ACh, 5-HT and NE of AD rats were significantly increased after the treatment with the three prescriptions, respectively.
CONCLUSIONThese prescriptions had some up regulating effects on hippocampus neurotransmitters in rats, which had already decreased due to dementia.
