The characteristics of opioid receptors distributed in the neurons of habenula.
- Author:
Sui-sheng WU
1
;
Chun-xiao ZHANG
;
Min HUANG
;
Xiao-jie CAO
;
Shao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Animals, Newborn; Habenula; metabolism; Neural Pathways; Neurons; metabolism; Potassium Channels; metabolism; Rats; Receptors, Opioid; metabolism
- From:Chinese Journal of Applied Physiology 2005;21(1):64-67
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the types of receptors distributed in MHb and LHb.
METHODSRecording the currents of potassium channels in Hb neurons isolated from the rats 10-15 days after birth. To distinguish the types of receptors distributed in MHb and LHb by using the agonists of mu receptor DAMGO, and sigma receptor DPDPE.
RESULTSTwo types of current of K+ channels were recorded, the transient rectifier and delayed rectifier potassium channels. DAMGO or DPDPE increased the intensity of current of K+ channels.
CONCLUSIONIn MHb there was a higher density of sigma receptor, and in LHb a higher density of mu receptor distributed.
