Protective effects of glucagon-like peptide 2 on intestinal ischemia/reperfusion injury in mice.
- Author:
Li-li GUAN
1
;
De-zheng GONG
;
Nan TIAN
;
Yuan ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Glucagon-Like Peptide 2; pharmacology; Intestinal Mucosa; drug effects; pathology; physiopathology; Intestine, Small; blood supply; Male; Mice; Mice, Inbred Strains; Reperfusion Injury; pathology; physiopathology
- From: Chinese Journal of Applied Physiology 2005;21(2):192-194
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the protective effects of glucagon-like peptide 2(GLP-2) on intestinal ischemia/reperfusion (I/R) injury in mice.
METHODSIntestinal ischemia/reperfusion model in mice were set up and 32 mice of Kunming species were divided randomly into 4 groups (n=8): Sham group, I/R group, I/R + GLP-2 group and I/R + glutamine group. The morphologic changes of intestinal mucosa were observed under LM. The villus height and crypt depth of intestine, the activity of diamine oxidase (DAO) in intestine and bacterial translocation rates of mesenteric lymph nodes (MLN) were detected.
RESULTSCompared with sham operation group, the intestinal villi were sloughed in I/R group with decreased villus height and crypt depth (P < 0.01), the DAO activities were decreased (P < 0.01), and MLN bacterial translocation rates were increased (P < 0.05). While GLP-2 administration improved the villus damage, increased DAO activity (P < 0.01), and decreased MLN bacterial translocation rates (P < 0.05), compared with I/R group.
CONCLUSIONGLP-2 have protective effects on intestinal morphology and barrier function after ischemia/reperfusion injury in mice.
