Effects of cholesterol rich diet on blood coagulative and fibrinolytic activities in male rabbits.
- Author:
Quan-jin SI
1
;
Xiao-ying LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cholesterol; blood; Cholesterol, Dietary; pharmacology; Fibrinolysis; drug effects; Hyperlipidemias; blood; Lipoproteins, HDL; blood; Male; Partial Thromboplastin Time; Rabbits
- From:Chinese Journal of Applied Physiology 2005;21(2):224-226
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the effects of cholesterol rich diet on the activities of blood coagulative and fibrinolytic systems in male rabbits.
METHODS14 male New Zealand white rabbits were randomized to cholesterol rich diet(CRD) group and common diet (control) group. Rabbits in CRD group were fed with 1% cholesterol embedded diet and those in the control group were fed with common diet. Levels of blood TG, TC, LDL, HDL, Lp(a), apoA1, apoB, FIB, D-dimers and FDP, PT and APTT, activity of ADP, AT-III, PLG and alpha2-PI were tested in all rabbits before given cholesterol rich diet and after 12 weeks' feeding with different kinds of diet.
RESULTSLevels of blood TG, TC, LDL, HDL, Lp(a), apoA1, apoB, FIB, D-dimers in CRD group were all elevated significantly compared with those in the control group and the baseline levels. PT and APTT were shortened, ADP, PLG and alpha2-PI activity were increased in CRD group.
CONCLUSIONCholesterol rich diet not only is the direct cause of hyperlipidemia but also can increase the coagulative activity and inhibit the fibrinolytic activity and promoting the evolution of arteriosclerosis.
