Economic evaluation on diagnosis of congenital cytomegalovirus infection by fluorescent quantitative polymerase chain reaction in neonates.
- Author:
Lu-Quan LI
1
;
Jia-Lin YU
;
Jun-Jie TAN
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Viral; urine; Cytomegalovirus Infections; congenital; diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Fluorescence; Humans; Immunoglobulin G; urine; Immunoglobulin M; urine; Infant, Newborn; Male; Polymerase Chain Reaction; economics; methods
- From: Chinese Journal of Contemporary Pediatrics 2010;12(10):796-798
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the cost-effectiveness of the diagnosis of congenital cytomegalovirus (CMV) infection by fluorescent quantitative polymerase chain reaction (FQ-PCR) in neonates.
METHODSSerum CMV immunoglobulin M (CMV-IgM) and CMV-IgG were detected using ELISA in 610 neonates aged less than 14 days. CMV DNA content was detected by FQ-PCR. The cost-effectiveness analysis was then performed.
RESULTSThe positive rate of FQ-PCR in neonates with positive CMV-IgM was 42.9% (15/35), while, 2.9% (16/547) in neonates with positive CMV-IgG. The mean logarithm values of CMV DNA in neonates with positive CMV-IgM were higher than those in neonates with positive CMV-IgG (5.79±1.24 vs 4.11±0.87; P<0.01). The costs of the diagnosis of CMV infection by FQ-PCR were 256 RMB/case in neonates with positive CMV-IgM, and 3 760 RMB/case in neonates with positive CMV-IgG.
CONCLUSIONSThe CMV DNA content in neonates with positive CMV-IgM is higher than that in neonates with positive CMV-IgG. Diagnosis of congenital CMV infection by FQ-PCR in neonates with positive CMV-IgG is not suitable for large scale epidemiological survey because of high cost-effectiveness ratio.
