Levels of cytokines in peripheral blood of premature infants with chronic lung disease.
- Author:
Ying LUO
1
;
Li-Jun TANG
;
Wei-Min HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Chronic Disease; Cytokines; blood; Female; Humans; Infant, Newborn; Infant, Premature; immunology; Lung Diseases; immunology; Male
- From: Chinese Journal of Contemporary Pediatrics 2010;12(11):855-857
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study examined the levels of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α) in peripheral blood of premature infants with chronic lung disease (CLD) in order to investigate the possible role of immunologic factors in CLD.
METHODSTwenty-six premature infants who had been admitted to the neonatal intensive care unit for 28 days were classified into CLD (n=14) and non-CLD (control, n=12) groups. IL-1β, IL-6, IL-8 and TNF-α concentrations in peripheral blood were measured by multiplex technique (Bio-plex).
RESULTSThere were no significant differences in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α between the two groups.
CONCLUSIONSThere are no significant changes in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α in premature infants with CLD on the non-acute phase. Immunologic factors might not play a key role in CLD on the phase.
