Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder.
- Author:
Yong-Ji DENG
1
;
Geng MA
;
Yun-Fei GUO
;
Zheng GE
;
Ru-Gang LU
;
Li-Xia WANG
;
Hao-Bo ZHU
;
Chen-Jun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Benzhydryl Compounds; adverse effects; therapeutic use; Child; Child, Preschool; Cresols; adverse effects; therapeutic use; Female; Humans; Male; Mandelic Acids; adverse effects; therapeutic use; Muscarinic Antagonists; therapeutic use; Phenylpropanolamine; adverse effects; therapeutic use; Tolterodine Tartrate; Urinary Bladder, Overactive; drug therapy
- From: Chinese Journal of Contemporary Pediatrics 2011;13(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children.
METHODSA total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each): placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment.
RESULTSThe effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05).
CONCLUSIONSTolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.
