Predictive value of c-met for long-term mortality in patients with esophageal squamous cell carcinoma.
- Author:
Zi-Hao ZHOU
1
,
2
;
Gang CHEN
;
Zhi XIE
;
Ji-Ming TANG
;
Xiao-Song BEN
;
Liang XIE
;
Hai-Yu ZHOU
;
Dong-Kun ZHANG
;
Xiong YE
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; diagnosis; metabolism; Esophageal Neoplasms; diagnosis; metabolism; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Proto-Oncogene Proteins c-met; metabolism; Risk Factors
- From: Journal of Southern Medical University 2016;36(8):1153-1156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of c-met protein with the clinical staging and cell differentiation of esophageal squamous cell carcinoma (ESCC).
METHODSA total of 100 patients with ESCC were enrolled were examined for expression of c-met protein using immunohistochemistry, and the patients in negative and positive c-met expression groups were compared for clinicopathological characteristics and overall survival.
RESULTSs The 100 ESCC patients included 67 male and 33 female patients with a median age of 59 years; 49 of the patients were negative and 51 were positive for c-met expression. Positive c-met expression was significantly correlated with advanced TMN stages and lower tumor differentiation. Kaplan-Meier survival curve showed that the median survival time of c-met-positive patients was significantly reduced compared with that of c-met-negative patients (30.9 vs 48.2 months, P<0.05). COX regression analysis showed that c-met was a independent risk factor for the overall survival of the patients (HR: 2.34, 95% CI: 1.63-4.54, P<0.05).
CONCLUSIONA positive expression of c-met protein is significantly correlated with an advanced TMN stage, lower tumor differentiation and a poor prognosis, and may serve as a indicator for predicting the prognosis of ESCC.
