Variations of peripheral blood autoantibody, immunoglobuliln, and complement levels in patients with non-lactational mastitis and their clinical significances.
- Author:
Rui XU
1
;
Qian-Qian GUO
;
Le-Ping YANG
;
Mi-Lin LAI
;
Lin TONG
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Antinuclear; blood; Autoantibodies; blood; Autoimmune Diseases; blood; diagnosis; Case-Control Studies; Complement System Proteins; analysis; Female; Humans; Mastitis; blood; diagnosis
- From: Journal of Southern Medical University 2016;36(8):1157-1159
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the variations in peripheral blood levels of autoantibodies, immunoglobulilns and complements in patients with non-lactational mastitis and investigate whether non-lactational mastitis is an autoimmune disease with immune dysfunction.
METHODSSeven-eight patients with non-lactational mastitis treated in our hospital between September 2013 and May 2015 and 88 healthy women (control) were examined for peripheral blood levels of antinuclear antibody (ANA), anti-histone antibody (AHA), immunoglobulins (IgA, IgM, and IgG) and complements (C3, C4, and total complements).
RESULTSs Of the 78 patients with non-lactational mastitis, 50 (64.10%) were positive of ANA showing mainly the granular and cytoplasmic granular fluorescence patterns, and the positivity rate was significantly higher than that in the control group (P<0.000). Twenty-eight (36.00%) of the patients were positive of AHA, a rate significantly higher than that in the control group (P<0.000). The levels of IgA, IgM, C4, and total complements levels were all significantly elevated in the patients compared with those in the control group (P<0.05).
CONCLUSIONPatients with non-lactational mastitis have abnormal changes in peripheral blood levels of immunoglobulins and complements with high positivity rates for ANA and AHA, indicating that non-lactational mastitis is an autoimmune disease with immune dysfunction.
