Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registry.
10.11005/jbm.2015.22.1.29
- Author:
Gi Hyeon SEO
1
;
Young Kyun LEE
;
Yong Chan HA
Author Information
1. Health Insurance Review and Assessment Service, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Alpha-blocker;
Hip fracture;
Registries
- MeSH:
Hip;
Hip Fractures*;
Humans;
Hypotension, Orthostatic;
Incidence;
Male;
Prescriptions;
Registries
- From:Journal of Bone Metabolism
2015;22(1):29-32
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database. METHODS: We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR). RESULTS: Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker. CONCLUSIONS: Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
