Effect of perioperative blood transfusion on the prognosis of gastric cancer.

Jingli Cui; Jingyu Deng; Yachao Hou; Xingming Xie; Xuewei Ding; Xiaona Wang; Hongjie Zhan; Li Zhang; Han Liang; Email: Tjlianghan@126com

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Effect of perioperative blood transfusion on the prognosis of gastric cancer.

Author: Jingli CUI ¹ ; Jingyu DENG ¹ ; Yachao HOU ¹ ; Xingming XIE ¹ ; Xuewei DING ¹ ; Xiaona WANG ¹ ; Hongjie ZHAN ¹ ; Li ZHANG ¹ ; Han LIANG ² ; Email: TJLIANGHAN@126.COM.
Author Information

1. Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China.
2. Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China
Publication Type:Journal Article
MeSH: Analysis of Variance; Blood Transfusion; mortality; Humans; Kaplan-Meier Estimate; Lymph Node Excision; Lymphatic Metastasis; Perioperative Period; Prognosis; Retrospective Studies; Stomach Neoplasms; mortality; pathology; surgery; Survival Rate
From: Chinese Journal of Oncology 2015;37(11):837-840
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the association of perioperative blood transfusion (PBT) with survival of gastric cancer after surgery.
METHODSWe retrospectively reviewed the medical records of 1 000 gastric cancer patients, including 738 non-transfused (73.8%) and 262 transfused (26.2%) cases. A one to one match was created using propensity score analysis, except preoperative hemoglobin level and operative blood loss. The survival was analyzed by Kaplan-Meier survival model.
RESULTSThe 5-year survival rate of the 1 000 cases of gastric cancer patients was 39.9%. Before matching, there was a significant difference between transfused group (33.6%) and non-transfused group (49.1%, P<0.005). Univariate analysis showed that age, tumor size, hemoglobin level, albumin level, depth of invasion, lymph node metastasis, lymph node dissection, surgery mode, adjuvant chemotherapy, blood loss and blood transfusion during perioperative period were associated with prognosis in the gastric cancer patients (all P<0.05). Multivariate analysis showed that tumor invasion, lymph node metastasis, lymph node dissection, chemotherapy and perioperative blood transfusion were independent prognostic factors in gastric cancer (all P<0.05). After matching, the 5-year survival rate of the 262 non-transfused patients was 37.7%, while that of the 262 transfused patients was 33.6% (P>0.05).
CONCLUSIONSPerioperative blood transfusion has no significant effect on the prognosis of gastric cancer patients.