Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population.
- Author:
Feifei HU
1
;
Hengdong ZHANG
;
Xin LI
;
Qian BIAN
;
Baoli ZHU
2
;
Zhengdong ZHANG
3
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Auditory Threshold; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; genetics; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Hearing Loss, Noise-Induced; genetics; Humans; Male; Middle Aged; Noise, Occupational; Polymorphism, Single Nucleotide; Risk Factors
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2014;32(2):104-107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.
METHODSThis case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.
RESULTSTT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI: 1.14-2.52).
CONCLUSIONThe study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.
