Association of GSTM1 and GSTT1 polymorphisms with noise-induced hearing loss: a meta-analysis.
- Author:
Sijing ZHOU
1
;
Ran WANG
2
;
Junsheng ZHOU
;
Shengping LIU
;
Bin ZHOU
;
Lei CAO
Author Information
- Publication Type:Journal Article
- MeSH: Glutathione Transferase; genetics; Hearing Loss, Noise-Induced; genetics; Humans; Polymorphism, Single Nucleotide
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2014;32(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the association of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms with noise-induced hearing loss.
METHODSThe Cochrane library, PubMed, OVID, EMBASE, Springer, Wanfang Data, VIP, CNKI, and CBM were searched to collect case-control studies on GSTM1 or GSTT1 polymorphism and noise-induced hearing loss. The articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using Revman 5.0.
RESULTSFive studies were included in the meta-analysis. The meta-analysis and subgroup analysis showed that the persons with GSTM1 null genotype had an increased risk of noise-induced hearing loss compared with those with GSTM1 wild genotype (OR = 1.37, 95%CI: 1.13∼1.66); in the Chinese population, the risk of noise-induced hearing loss was higher in persons with GSTM1 null genotype than in those with GSTM1 wild genotype (OR = 1.5, 95%CI: 1.2∼1.86); there was no significant difference in the risk of noise-induced hearing loss between persons with GSTT1 null and wild genotypes.
CONCLUSIONGSTM1 polymorphism is related to noise-induced hearing loss, but GSTT1 polymorphism is unrelated to this condition.
