Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men.
- Author:
Juan HUI
1
;
Jian-Ye WANG
;
Xiao-Hong SHI
;
Yao-Guang ZHANG
;
Ming LIU
;
Xin WANG
;
Na-Na WANG
;
Xin CHEN
;
Si-Ying LIANG
;
Dong WEI
;
Fan ZHAO
;
Yu-Hong ZHANG
;
Ze YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; genetics; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Genotype; Homeodomain Proteins; genetics; Humans; LIM Domain Proteins; genetics; Male; Middle Aged; Organic Cation Transport Proteins; genetics; Polymorphism, Single Nucleotide; Prostatic Neoplasms; genetics; Risk Factors; Transcription Factors; genetics
- From: National Journal of Andrology 2012;18(5):404-411
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of prostate cancer (PCa) with PDLIM5 (rs17021918, T), SLC22A3 (rs9364554, C) and NKX3-1 (rs1512268, A) in Chinese men.
METHODSWe included 124 PCa patients and 138 normal controls in this study, compared the alleles and genotypes of PDLIM5 (rs17021918, T) , SLC22A3 (rs9364554, C) and NKX3-1 (rs1512268, A) of the two groups, and explored the association of each of the genes with the age, body mass index (BMI), Gleason score, PSA level and tumor stage of the patients. We analyzed the gene-gene interaction using the multifactor dimensionality reduction method (MDR).
RESULTSThere were no statistically significant differences in the frequency distribution of the risk alleles and genotypes of PDLIM5, SLC22A3 and NKX3-1 between the case and control groups (P > 0.05), nor were the three gene loci significantly associated with the age, Gleason score, PSA level and pathological grade of the PCa patients (CP < 0.05). MDR analysis showed no interaction between PDLIM5 and NKX3-1, but tree-diagram analysis revealed a possible synergistic action of the two polymorphism loci.
CONCLUSIONPCa might not be associated with PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) in Chinese men. However, PDLIM5 and NKX3-1 might have a synergistic action on the risk PCa.
