Tadalafil improves total testosterone, IIEF score and SEP in old and middle-aged males with late-onset hypogonadism.
- Author:
Xi-Kun WANG
1
;
Li LUO
;
Sen WANG
;
Jun LI
;
Wen-Xiong LI
Author Information
- Publication Type:Journal Article
- MeSH: Carbolines; therapeutic use; Erectile Dysfunction; etiology; Humans; Hypogonadism; drug therapy; physiopathology; psychology; Male; Middle Aged; Sexual Behavior; Tadalafil; Testosterone; analogs & derivatives; analysis; therapeutic use; Treatment Outcome
- From: National Journal of Andrology 2012;18(5):475-477
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the clinical effect of tadalafil combined with testosterone undecanoate on late-onset hypogonadism (LOH) in old and middle-aged males.
METHODSA total of 125 old and middle-aged (40 to 60 years) males with LOH were randomly assigned to a treatment group (n = 65) and a control group (n = 60) to be treated with tadalafil + testosterone undecanoate and testosterone undecanoate alone, respectively. We compared the levels of total testosterone (T), IIEF scores and the patients' sexual encounter profile (SEP) diaries before and 4 weeks after medication.
RESULTSThe T level, IIEF score and SEP score were significantly improved in both groups after medication as compared with the baseline (P < 0.05), and even more so in the treatment than in the control group (P < 0.05).
CONCLUSIONTadalafil combined with testosterone undecanoate, superior to testosterone undecanoate alone, can improve the T level, IIEF score and SEP score in old and middle-aged males with LOH and increase their sexual satisfaction and self-confidence.
