The Early Onset of Disease May Be a Risk Factor for Decreased Bone Mineral Density in Patients with Inflammatory Bowel Disease.
- Author:
Hwa Jong KIM
1
;
Su Jin HONG
;
Young Woo JEON
;
Jae Pil HAN
;
Seung Hyo HAN
;
Jee Heon KANG
;
Jae Woong TAE
;
Hee Sook LIM
;
Hee Kyung KIM
;
Bong Min KO
;
Moon Sung LEE
Author Information
- Publication Type:Original Article
- Keywords: Inflammatory bowel diseases; Bone density; Steroids; Age
- MeSH: Bone Density; Hip; Humans; Inflammatory Bowel Diseases; Multivariate Analysis; Osteoporosis; Risk Factors; Spine; Steroids
- From:Clinical Endoscopy 2013;46(1):71-76
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The pathogenesis of bone loss in patients with inflammatory bowel disease (IBD) is complex, multifactorial, and only partly understood. We aimed to examine the extent and risk factors of bone mass reduction and to analyze the impact of early onset of a disease before attaining peak bone mass in IBD patients. METHODS: We compared the risk factors for osteoporosis and BMD at the lumbar spine and the hip bone in IBD patients. RESULTS: A total of 44 patients with IBD were enrolled. Twenty-one and 23 patients were diagnosed as IBD before and after the age of 30 and designated as group A and group B, respectively. Group A had significant bone mass reduction at the lumbar spine than group B (BMD, 1.01+/-0.10 vs. 1.14+/-0.17, p<0.01; T-score, -1.22+/-0.84 vs. -0.08+/-1.39, p<0.01; Z-score, -1.11+/-0.81 vs. -0.03+/-1.32, p<0.01, respectively). Multivariate analysis showed that patients diagnosed as IBD before the age of 30 had possible risk factor of bone mass reduction (hazard ratio, 3.96; p=0.06). CONCLUSIONS: Bone mass reduction was more severe in patients who were diagnosed with IBD before the age of 30 than in those diagnosed after the age of 30.
