Shengjing prescription improves semen parameters of oligoasthenozoospermia patients: efficacy and mechanism.
- Author:
Zhen-Gao SUN
1
;
Fang LIAN
;
Kun-Peng JIANG
;
Jian-Wei ZHANG
;
Feng-Mei MA
;
Ning ZHANG
;
Jin-Long SUN
;
Wu-Wen YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asthenozoospermia; drug therapy; physiopathology; Drugs, Chinese Herbal; therapeutic use; Humans; Infertility, Male; Male; Phytotherapy; Sperm Count; Sperm Motility; Treatment Outcome; Vitamin E; therapeutic use
- From: National Journal of Andrology 2012;18(8):764-767
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical efficacy of Shengjing prescription for oligoasthenozoospermia and its action mechanism.
METHODSWe equally assigned 120 patients with oligoasthenozoospermia to receive Shengjing prescription (treatment group) and vitamin E (control group), respectively, for 12 weeks. Before and after the treatment, were obtained sperm concentration, sperm motility, the percentage of morphologically normal sperm, the levels of serum follicle-stimulating hormone (FSH), testosterone (T) and luteinizing hormone (LH), sperm DNA fragmentation index (DFI), the percentage of hypotonic swelling sperm, and the levels of seminal plasma elastase, x-glucosidase, fructose, zinc and acrosin.
RESULTSCompared with vitamin E, Shengling prescription significantly improved sperm concentration, motility and morphology (P < 0.01), decreased the serum FSH level, elevated the serum T level (P <0. 01) , reduced DFI and seminal plasma elastase, and increased the percentage of hypotonic swelling sperm as well as the levels of seminal plasma cx-glucosidase, fructose, zinc and acrosin.
CONCLUSIONShengjing prescription improves semen parameters of patients with oligoasthenozoospermia at multiple levels and through multiple channels.
