Deacetylase SIRT1 and vascular endothelial function.
- Author:
Zan WAN
1
;
Wen YU
;
Yun CHEN
;
Yu-Tian DAI
Author Information
1. Department of Urology, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.
- Publication Type:Journal Article
- MeSH:
Endothelium, Vascular;
physiology;
Erectile Dysfunction;
Forkhead Box Protein O1;
Forkhead Transcription Factors;
metabolism;
Humans;
Male;
NAD;
metabolism;
NF-kappa B;
metabolism;
Nitric Oxide Synthase Type III;
metabolism;
Oxidative Stress;
Sirtuin 1;
physiology;
Tumor Suppressor Protein p53;
metabolism
- From:
National Journal of Andrology
2012;18(9):831-834
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator factor 2-related enzyme 1 (Sirtuins 1, SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, which can deacetylate histone and non-histone proteins and other transcription factors, and is involved in the regulation of many physiological functions, including gene transcription, energy metabolism, cell senescence and oxidative stress. Recent studies show that through adjusting the activity of endothelial nitric oxide syntheses (eNOS), p53, forkhead box class O (FOXO) and nuclear factor kappa B (NF-kappaB), SIRT1 can protect the functions of vascular endothelia and nerves in a variety of pathological conditions. Therefore, SIRT1 may be used as a potential therapeutic target of these diseases, particularly erectile dysfunction, which are associated with endothelial dysfunction.
