Hepatocyte Expressions in Hepatocellular Carcinomas, Gastrointestinal Neoplasms, and Non-neoplastic Gastrointestinal Mucosa: its Role as a Diagnostic Marker.
10.3346/jkms.2003.18.6.842
- Author:
Hye Seung LEE
1
;
Woo Ho KIM
;
Gyeong Hoon KANG
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. ghkang@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Carcinoma;
Hepatocellular;
Hepatocytes;
Hepatocyte-Paraffin 1;
CD10 Antigen;
Immunohistochemistry
- MeSH:
Adult;
Antibodies, Monoclonal/metabolism;
Carcinoma, Hepatocellular/*metabolism/pathology;
Diagnosis, Differential;
Epitopes;
Gastric Mucosa/cytology/*metabolism;
Gastrointestinal Neoplasms/*metabolism/pathology;
Hepatocytes/cytology/*metabolism;
Human;
Immunohistochemistry;
Intestinal Mucosa/cytology/*metabolism;
Liver Neoplasms/*metabolism/pathology;
Neprilysin/metabolism;
Support, Non-U.S. Gov't;
Tumor Markers, Biological
- From:Journal of Korean Medical Science
2003;18(6):842-848
- CountryRepublic of Korea
- Language:English
-
Abstract:
We performed immunohistochemical staining against Hepatocyte (Hep) and CD10 antibodies in 75 hepatocellular carcinoma (HCC), 50 cholangiocarcinomas, 49 colorectal adenocarcinomas, and 308 gastric adenocarcinomas by tissue array method. We also evaluated the various non-neoplastic adult tissues and fetal digestive organs. Hep was expressed in 80% of HCCs, and HCCs without Hep expression were more likely to have a higher Edmondson & Steiner grade than HCCs with Hep expression (p=0.004). In non-HCCs, 16% of cholangiocarcinomas, 8.2% of colorectal carcinomas, and 44.2% of gastric carcinomas expressed Hep. Gastric carcinomas with Hep expression were significantly associated with early gastric carcinomas (p<0.001). In non-neoplastic tissues, Hep was found expressed in normal hepatocytes, small intestinal mucosa, and intestinal metaplasia of the stomach. Fetal hepatocytes expressed Hep after 19 weeks of gestation. CD10 was detected in 46.7% (35/75) of HCCs, and canalicular staining pattern was predominant in HCCs. In conclusion, the expression of Hep and CD10 may help to distinguish HCCs from non-HCCs.
