Acute Hemolytic Transfusion Reactions due to Multiple Alloantibodies Including Anti-E, Anti-c and Anti-Jk(b).
10.3346/jkms.2003.18.6.894
- Author:
Tae Sung PARK
1
;
Ki Uk KIM
;
Woo Jin JEONG
;
Hyung Hoi KIM
;
Chulhun L CHANG
;
Joo Seop CHUNG
;
Goon Jae CHO
;
Eun Yup LEE
;
Han Chul SON
Author Information
1. Department of Laboratory Medicine, Pusan National University College of Medicine, Busan, Korea. hhkim@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Blood Transfusion;
Blood Grouping and Cross Matching;
Blood Group Incompatibility;
Isoantibodies
- MeSH:
Adult;
Blood Group Antigens/immunology;
*Blood Group Incompatibility;
Blood Grouping and Crossmatching/methods;
Blood Transfusion/*adverse effects;
Female;
Hemolysis/*immunology;
Human;
Isoantibodies/*immunology;
Male;
Pregnancy
- From:Journal of Korean Medical Science
2003;18(6):894-896
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of two consecutive episodes of acute hemolytic transfusion reactions (HTRs) due to multiple alloantibodies in a 34-yr-old man who suffered from avascular necrosis of left femoral head. He received five units of packed red blood cells (RBCs) during surgery. Then the transfusion of packed RBCs was required nine days after the surgery because of the unexplained drop in hemoglobin level. The transfusion of the first two units resulted in fever and brown-colored urine, but he received the transfusion of another packed RBCs the next day. He experienced even more severe symptoms during the transfusion of the first unit. We performed antibody screening test, and it showed positive results. Multiple alloantibodies including anti-E, anti-c and anti-Jk(b) were detected by antibody identification study. Acute HTRs due to multiple alloantibodies were diagnosed, and the supportive cares were done for 6 days. We suggest the antibody screening test should be included in the panel of pretransfusion tests for safer transfusion, and it is particularly mandatory for the patients with multiple transfusions, pregnant women, and preoperative patients.
