Effect of HSV-1 infection on NGF and its receptor expression in human glioma cells.
- Author:
Yun HOU
1
;
Ling LI
;
Ming HU
;
Guang-Yu JIANG
;
Qian WANG
;
Dong-Meng QIAN
;
Zhi-Yong YAN
;
Wei ZHAO
;
Xu-Xia SONG
;
Bin WANG
Author Information
1. Department of Microbiology, Key Laboratory of Medicine and Biotechnology of Qingdao, Qingdao University Medical College, Qingdao 266071, China. houy20082008@163.com
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cell Line, Tumor;
Gene Expression;
Glioma;
genetics;
metabolism;
physiopathology;
virology;
Herpes Simplex;
genetics;
metabolism;
physiopathology;
virology;
Herpesvirus 1, Human;
genetics;
physiology;
Humans;
Nerve Growth Factor;
genetics;
metabolism;
Receptor, Nerve Growth Factor;
genetics;
metabolism;
Receptor, trkA;
genetics;
metabolism;
Virus Replication
- From:
Chinese Journal of Virology
2010;26(6):477-482
- CountryChina
- Language:Chinese
-
Abstract:
Nerve growth factor (NGF) is mainly secreted by the neuroglia cells, which can exert biological effect through its receptors on the specific target cell surface. NGF is closely related to neurocyte growth, differentiation and apoptosis. As a neurotropic virus, HSV-1 an easily lead to neurocyte, neuroglia cells death or apoptosis. In this study, the U251 human glioma cells were chosen as target cells to study the change of NGF and its receptors in the apoptosis process of HSV-1 infection. Our results showed that U251 cells were permissive to HSV-1 replication. In the apoptosis process of HSV-1 infected U251 cells, the expression of both NGF and P75NTR increased and then decreased, while the expression of TrkA decreased gradually. These result indicated that HSV-1 was able to induce the abnormal expression of NGF and its receptors in U251 cells.
