Temporal and spatial population dynamics of rabies virus isolates in China.
- Author:
Sheng-Li MENG
1
;
Ge-Lin XU
;
Yong-Liang LEI
;
Jie WU
;
Jia-Xin YAN
;
Xiao-Ming YANG
Author Information
1. Wuhan Institute of Biological Products, Wuhan 430060, China.
- Publication Type:Journal Article
- MeSH:
China;
Evolution, Molecular;
Monte Carlo Method;
Phylogeography;
Rabies virus;
genetics;
isolation & purification
- From:
Chinese Journal of Virology
2011;27(3):231-237
- CountryChina
- Language:Chinese
-
Abstract:
In order to study phylogeography, population dynamics and molecular evolution of rabies viruses (RABVs) isolates from China, especially spatio-temporal dynamics, the timescale of RABVs evolution and its pattern of migration, we performed an extensive comparative analysis of RABV N gene sequence data, representing 167 isolates sampled from 20 provinces in a 78-year period (from 1931 through 2009). The available Chinese isolates could be divided into two distinct clades:Phylogroup clades I comprised Chinese group 1-4; Phylogroup clades II contained Chinese group 5-8. We found no evidence for positive selection (dN/dS>1) acting at any codon and found strong selective constraints for N gene. Bayesian Markov Chain Monte Carlo (MCMC) analysis suggested that the Chinese rabies viruses originated within the last 2000 years and the mean rates of nucleotide substitution for the N gene were approximately 4 x 10(-4) substitutions per site per year. The analyses of the spatial and spatio-temporal evolution indicated that RABV isolates from China migrated among different Provinces.
